Minggu, 31 Oktober 2010

The End of Memory: A Natural History of Aging and Alzheimer's, by Jay Ingram

The End of Memory: A Natural History of Aging and Alzheimer's, by Jay Ingram

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The End of Memory: A Natural History of Aging and Alzheimer's, by Jay Ingram

The End of Memory: A Natural History of Aging and Alzheimer's, by Jay Ingram



The End of Memory: A Natural History of Aging and Alzheimer's, by Jay Ingram

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It is a wicked disease that robs its victims of their memories, their ability to think clearly, and ultimately their lives. For centuries, those afflicted by Alzheimer's disease have suffered its debilitating effects while family members sit by, watching their loved ones disappear a little more each day until the person they used to know is gone forever. The disease was first described by German psychologist and neurologist Alois Alzheimer in 1906. One hundred years and a great deal of scientific effort later, much more is known about Alzheimer's, but it still affects millions around the world, and there is no cure in sight.

In The End of Memory, award-winning science author Jay Ingram writes a biography of this disease that attacks the brains of patients. He charts the history of the disease from before it was noted by Alois Alzheimer through to the twenty-first century, explains the fascinating science of plaques and tangles, recounts the efforts to understand and combat the disease, and introduces us to the passionate researchers who are working to find a cure.

An illuminating biography of "the plague of the twenty-first century" and scientists' efforts to understand and, they hope, prevent it, The End of Memory is a book for those who want to find out the true story behind an affliction that courses through families and wreaks havoc on the lives of millions.

The End of Memory: A Natural History of Aging and Alzheimer's, by Jay Ingram

  • Amazon Sales Rank: #99457 in Books
  • Published on: 2015-09-29
  • Released on: 2015-09-29
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.44" h x 1.10" w x 6.34" l, 1.00 pounds
  • Binding: Hardcover
  • 304 pages
The End of Memory: A Natural History of Aging and Alzheimer's, by Jay Ingram

Review

"In this deft overview, science writer Jay Ingram unravels the complexities of the science past and present." ―Nature

“In this riveting tale of Alzheimer's disease, Canadian science writer Ingram elegantly traces the history of the persistent and devastating ailment and the many medical researchers who have contributed to the public's understanding of it. ... With crackerjack storytelling and fast-paced prose, Ingram examines recent research into Alzheimer's. ... Ingram's first-rate medical writing makes this excellent history a must-read.” ―Publishers Weekly (starred review)

“A cogent and informative history of the disease and overview of current research. ... In clear, accessible, and upbeat prose, Ingram demonstrates his optimism about the possibility of aging and an agile mind, and he is hopeful about finding an effective treatment for sufferers.” ―Kirkus Reviews

“Highly readable and informative, this work is strongly recommended for readers interested in medicine, scientific research, or pathology.” ―Library Journal (starred review)

“Ingram's refreshing voice transforms mysteries into compelling reading. In the tradition of Stephen Jay Gould and Oliver Sacks, [Ingram] manages a difficult trick-making the minutiae of science seem alluring to the uninitiated.” ―Maclean’s (Canada)

“Jay Ingram has taken on the role of alchemist: he turns the lead of scientific jargon into literary gold.” ―Calgary Herald (Canada)

“Ingram is a wizard at transforming complex curiosities of the natural and physical sciences into entertaining anecdotes.” ―The Edmonton Sun (Canada)

“Ingram, a veteran science writer and television host, combines snappy writing with interesting and unusual science.” ―Booklist

About the Author Jay Ingram is an award-winning science writer and broadcaster. He hosted CBC Radio's Quirks & Quarks, was cohost and producer of Discovery Channel Canada's Daily Planet, and is the author of twelve previous books. He is a distinguished alumnus of the University of Alberta, has received five honorary doctorates, and is a member of the Order of Canada. He lives in Alberta, Canada.


The End of Memory: A Natural History of Aging and Alzheimer's, by Jay Ingram

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Most helpful customer reviews

4 of 4 people found the following review helpful. Well-written and well-documented overview of Alzheimer's research By Julie Richer This book caught my eye in the new books section of my local library because my mother had Alzheimer's. It is a well-written overview of both the history of the study of Alzheimer's disease and current research. It's primarily about science and is well-documented with footnotes for readers who want to delve deeper into particular areas. It covers such topics as the heredity of early onset Alzheimer's and other forms of dementia, the controversy surrounding whether plaques or tangles are causative or merely associated with the disease, whether aluminum intake affects your chances of getting Alzheimer's, gender differences, etc. Though not the main focus, the book also includes some recommendations on specific behaviors that will lessen your risk of getting the disease. If you want practical advice on caring for a patient with Alzheimer's or a first-person account of what having the disease is like, this is not the book for you. On the other hand, if you're an educated layperson who enjoys reading Scientific American articles that summarize recent advances in particular field, this fits the bill perfectly.

1 of 1 people found the following review helpful. A must read for anyone who wants to know about Alzheimer's disease By Stella The End of Memory by Jay Ingram is a complete and thorough, yet easy to read, review of all the current research in Alzheimer's disease written for the laymen, only 259 pages long.Ingram begins with an interesting history of Alzheimer's comparing it to normal aging. He describes the first recorded person to have early onset alzheimers disease, august deter, who was only 51 years old and died at age 56. It is noted that Alzheimer's disease has been described by the ancient Egyptians, however more recently Robert Katzman in 1976 was the first to state that senile dementia was actually Alzheimer's disease. In other words Alzheimer's was not a big deal until the 1970s.The author reviews the biology of aging which involves a fair amount of genetics: the fox O and Klotho genes, Abraham Tremblys research on the immortality of the hydra and the telomerase protective effect on the telomeres, the destruction of the telomere on the chromosome thought to be important in aging.The nature of plaques and tangles are discussed in detail as they relate to the etiology of Alzheimer's . The role of micro infarcts and vascular pathology is also reviewed.A full analysis of the famous Nun study and the London cab driver study are presented.The author provides a very full list of factors related to the disease including: Cognitive reserve, curcumin, being bilingual, being ambitious, being cynical, nutrition and exercise, hobbies and activities of daily life, gender, brain size, role of estrogen, and more.Special consideration is given to the relationship between diabetes, sugar consumption and Alzheimer's disease and why some are calling Alzheimer's disease diabetes 3. The author states that the single thing that can be done to protect against the disease is to cut down sugar consumption and avoid getting diabetes of late onset.The apoE gene and its significance in predicting whether someone will get the disease is explained well.Therapeutic medications such as aricept are explained and their mechanism of action with the neurotransmitter acetylcholine.In short no area of current research and history is left out. I highly recommend this book for anyone who wants to learn about Alzheimer's disease in a complete and uplifting way. I was interested myself, because like the author and the previous reviewer, i have Alzheimer's disease in my family. This is the fourth nonfiction book on the subject that I have read and I think it is the best and most useful and most importantly lets the reader know where they stand, explains the subject and provides some basic preventive measures that can be taken with the understanding that there is no cure. I also found that Ingram took some of the fear out of the disease, a critical thing to do for those of us worried about Alzheimer's disease. For example people are so worried about genetic analysis of Alzheimer's. Ingram points out that one third of Alzheimer's patients do not have the bad gene ApoE4 and that even if someone has two copies of the gene, there is only an increased risk, not a certainty of acquiring Alzheimers. There are a lot of reassurances here, things you might have thought you have to eat, you don't have to eat so much really. Things you may have felt guilty for not doing do not make a difference.My only criticism was that an entire chapter should not have been devoted to aluminum and instead a consideration of the role that brain training, I.e., luminosity, might play in preventing Alzheimer's disease.

0 of 0 people found the following review helpful. ... have described my thoughts when reading this book any better than when he wrote By H.A.A. Jay Ingram could not have described my thoughts when reading this book any better than when he wrote: "The science of Alzheimer's is sometimes bewilderingly complex." Having observed and cared for a loving grandmother who suffered from this neurological disease, I really appreciated understanding the history and science of Alzheimer's disease as I read this book. Jay Ingram writes in a way that is informative and interesting to read. I'm a high school student and was able to read this book in about a week of casual reading so 90% of people should be able to read/comprehend this book. I think everyone should read this book because of the prevalence of Alzheimer's disease in today's aging populating (as half of all people above age 85!!!). Great read - 9/10.

See all 6 customer reviews... The End of Memory: A Natural History of Aging and Alzheimer's, by Jay Ingram


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The End of Memory: A Natural History of Aging and Alzheimer's, by Jay Ingram

The End of Memory: A Natural History of Aging and Alzheimer's, by Jay Ingram

The End of Memory: A Natural History of Aging and Alzheimer's, by Jay Ingram
The End of Memory: A Natural History of Aging and Alzheimer's, by Jay Ingram

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